In The Lost and Damned for PC / Windows, the player assumes the role of Johnny Klebitz, one of more respected members of the titular The Lost motorcycle gang. Until recently, the protagonist was a temporary leader of the group, watching over the actions taken by the gang. When Billy Grey – the former leader of The Losts returns from prison, everything becomes more and more complicated. Valuable alliances Johnny has established are being broken, and a competitive gang – Angels of Death enters the crime scene fighting for control over different areas.